U.S. Highway 50, Colorado. U.S. Route 50 in Colorado is a significant east-west highway, traversing the state's middle and southern regions. Known as "America's Backbone," it's part of a coast-to-coast route and passes through diverse landscapes, from deserts and mountains to plains. The highway offers scenic drives, including views of Blue Mesa Reservoir and the Black Canyon of the Gunnison, and passes through towns like Delta, Montrose, and Gunnison. Please note all photos, videos and reels on