leucine-rich glioma inactivated 1 autoimmune limbic encephalitis LGI1 is a neuronal secreted protein released by presynaptic membrane that interacts with presynaptic ADAM23 and postsynaptic ADAM22 to affect the signal transduction between the synapses by the VGKCs and postsynaptic membrane α-amino-3-hydroxy-5-methyl-4-isoxazle propionate receptors (AMPAR). This combination is #necessary for the inhibition of signal conduction. LGI1 antibody reduces the interaction of LGI1–ADAM and aggregation of