ESPN's "Monday Night Football" matchup will have a major impact on both the AFC and NFC playoff pictures. Here's what to know about the Week 16 game.

San Francisco aims to improve playoff position while Indianapolis fights for postseason hopes with Philip Rivers at quarterback. Here's how to watch for free.

The Falcons have revealed their uniforms for Monday's prime-time showdown against the Rams. Atlanta will be wearing its black jerseys with red throwback helmets in Week 17 (see below).

Authorities in Florida are investigating a murder-suicide and the shooting of a 13-year-old girl after an argument spurred by a wife asking her husband to turn off the Monday Night Football game, cops say.

This week’s Monday Night Football features the San Francisco 49ers visiting the Indianapolis Colts. The 49ers are 10-4, but in third place in a hyper-competitive NFC West. They have three games to move up the rankings.

Brock Purdy, who threw a career-high five touchdowns, and the 49ers pulled away from the Colts on Monday night for a 48-27 win.

Daily Fantasy multimillionaire Mike McClure reveals his daily Fantasy football picks for Indianapolis vs. San Francisco on 'MNF'

The Arizona Cardinals held a top-five draft position for all of 24 hours before Monday Night Football pushed them down the order. After their Week 16 loss to the Atlanta Falcons, the Cardinals moved up from No.