GMCL1-dependent degradation of 53BP1 suppresses mitotic surveillance, tuning p53 activation thresholds that govern cell fate decisions and cellular responses after mitosis.

New research has discovered that reducing levels of the STAUFEN-1 protein can prevent neuron death caused by DNA damage and ...

University of Utah researchers at the Pulst-Scoles Laboratory have discovered that reducing levels of the STAUFEN-1 protein ...

When brain cells die in diseases like ALS (amyotrophic lateral sclerosis) and frontotemporal dementia, they often activate a ...

Dandelion root extract (DRE) exhibits promising anti-cancer properties, selectively eliminating colon cancer cells without ...

ABSTRACT: Abnormal cell division leading to chromosomal instability is a hallmark of cancer development. Accurate chromosome classification Lysis plays an important role in cell division, and the ...

1 Department of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo, China 2 Department of Radiotherapy Oncology, The First People’s Hospital of Yancheng, Jiangsu, Yancheng, ...

Rituximab combined with systemic chemotherapy significantly improves the rate of complete response in B-cell lymphomas. However, acquired rituximab resistance develops in most patients leading to ...

Neuronal apoptosis plays an essential role in the pathogenesis of brain injury after subarachnoid hemorrhage (SAH). BAP1 (BRCA1-associated protein 1) is considered to exert pro-apoptotic effects in ...