A new CRISPR-based one-off procedure that lowers "bad" cholesterol has been approved to enter Phase I human trial. If ...

Schizophrenia is a highly heterogeneous psychiatric disorder affecting ~1% of the global population, typically emerging in ...

Understanding human gene function in living organisms has long been hampered by fundamental differences between species.

In a new study, Chinese researchers have discovered the previously unrecognized role of alternative splicing of the DOC2A gene in schizophrenia.

Ever see a basset hound and find yourself wanting to (gently) grab its long, floppy ears and give them a little waggle? The ...

Data from a major U.S. clinical trial from the Alliance for Clinical Trials in Oncology has uncovered a genetic factor that may inform how to optimize the dosing of abiraterone, a widely used hormone ...

Discover the innovative TECHNO platform for full-length gene humanisation, enhancing models for human gene function.

Researchers at The University of Tokyo developed TECHNO, a two-step genome editing strategy that replaces entire mouse loci with human genomic DNA. The method integrates fragments over 200 kbp.

Humanized mouse models are essential for investigating human gene function; however, the complete replacement of mouse genes ...