When older adults living in nursing homes are prescribed the pain medicine tramadol alongside certain antidepressants, their risk of seizures may go up, according to a study published October 8, 2025, ...

Roughly 8.7 million Brits take antidepressants and around 50 million beta blocker prescriptions are handed out annually (Picture: Getty Images) People taking two widely used drugs could be at greater ...

Grapefruit juice is more than a breakfast staple — it’s a potent enzyme inhibitor that can dramatically alter how certain drugs are metabolized. This article explores how a tiny structural difference ...

Depression affects millions globally, presenting a significant challenge for effective treatment. Traditional approaches often rely on trial and error to find ...

A graphical summary illustrates the strategy used to identify CYP2D6 as a target for collateral lethality, which is driven by the widespread occurrence of loss of heterozygosity in cancer genomes.

Accurate prediction of CYP2D6 activity from genotype data is of utmost importance as CYP2D6 pharmacogenetic (PGx) testing is increasingly used to guide drug therapy. However, given the complexity of ...

(HealthDay News) — For older nursing home (NH) residents, use of CYP2D6-metabolized opioids concomitantly with CYP2D6-inhibiting antidepressants is associated with worsening pain and increased risk of ...

Trintellix (vortioxetine) is a prescription oral tablet used to treat depression. This drug can interact with other medications and some supplements. For example, Trintellix can interact with certain ...

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that is commonly diagnosed in children and adolescents, but it can persist into ...

Please provide your email address to receive an email when new articles are posted on . Patients who started oxycodone while taking fluoxetine or paroxetine were at increased risk for opioid overdose ...

—New research uncovers a possible link between CYP2D6 activity and the development of tardive dyskinesia in certain patients taking antipsychotics. Reviewed by Nicole Foubister, Clinical Assistant ...