Anthony Hopkins was well into his fifties when he became a Hollywood leading man, especially when he won the Oscar for Best Actor for playing Hannibal Lecter in The Silence of the Lambs in 1991.

Hopkins won an Academy Award for his portrayal of the cannibalizing serial killer Hannibal Lector The Silence of the Lambs. He spoke to Fresh Air in 1991 about the character's distinctive voice.