Holoprosencephaly is a condition characterized by the failure of embryonic forebrain, called prosencephalon. The forebrain fails to divide into the double lobes of the cerebral hemisphere. As a result ...

Holoprosencephaly (HPE) is a rare congenital anomaly in which an embryo’s brain does not properly divide into two halves, known as the left and right hemispheres. HPE affects brain development and can ...

Fetal magnetic resonance imaging can reliably spot holoprosencephaly as early as 18 gestational weeks, providing an opportunity to counsel families earlier in their pregnancy, according to new ...

Fetal magnetic resonance imaging (MRI) can reliably spot holoprosencephaly as early as 18 gestational weeks, providing an opportunity to counsel families earlier in their pregnancy, according to ...

A mild subtype of HPE is called middle interhemispheric variant (MIHF) or syntelencephaly. Alterations in minor genes <1%. These minor genes with low mutation frequency rates are tested only in ...