Maintaining cellular order is a major logistical challenge: Individual mammalian cells contain billions of protein molecules, ...

The enzyme E3 ligase plays a key role here by acting as a “broker” that mediates the labeling of the proteins to be degraded. A research team at Goethe University Frankfurt has now made the first ...

Maintaining cellular order is a major logistical challenge: Individual mammalian cells contain billions of protein molecules, which must be synthesized, deployed, and removed with precision.

E3 ligases are enzymes that act as molecular "broker" by binding specific target proteins and coordinating the transfer of ubiquitin from an E2 enzyme. As an E3 ligase recognizes only a restricted set ...

Nurix advances CLL therapy with NX-5948 showing 83% response, 22.1-month PFS, $680M cash, and $3B risk-adjusted sales ...

Blacksmith Medicines, Inc. (Blacksmith), a leading biopharma dedicated to discovering and developing therapeutics ...

Cells have a remarkable housekeeping system: Proteins that are no longer needed, defective, or potentially harmful are labeled with a molecular "tag" and dismantled in the cellular recycling machinery ...

Degrader of cancer protein IDO1 prevents cancer immune suppression by cancer and offers promising strategy to support ...

Ubiquitination is a crucial post-translational modification process where the small protein ubiquitin is attached to target proteins, marking them for degradation or altering their function. This ...

Korro Bio, Inc. ( KRRO) 44th Annual J.P. Morgan Healthcare Conference January 15, 2026 1:30 PM EST ...

CDK2-mediated TBK1 degradation via Dtx4 represents a previously unrecognized regulatory mechanism that modulates antiviral immunity in fish.