49ers thrash Colts behind Purdy’s 5 TD passes: Live updates and reaction from NFL ‘Monday Night Football’

The San Francisco 49ers have beaten the Indianapolis Colts 48-27 on “Monday Night Football” behind Brock Purdy ’s career-high ...

49ers vs Colts final score, results: Brock Purdy throws five touchdowns, 49ers control destiny after win vs. Colts

49ers vs Colts final score, results: Brock Purdy throws five touchdowns, 49ers control destiny after win vs. Colts originally ...

Brock Purdy's career-high five TD passes power 49ers past Philip Rivers' Colts on 'Monday Night Football'

The Week 16 edition of "Monday Night Football" between the Indianapolis Colts (8-7) and the San Francisco 49ers (11-4) will ...

Brock Purdy, San Francisco surging at right time: Colts vs. 49ers MNF takeaways

Philip Rivers starts again when he takes on the ferocious 49ers on "Monday Night Football." Here's score, highlights, stats ...

49ers vs. Colts takeaways: Brock Purdy’s 5 TDs put Philip Rivers, Indy on the brink

Purdy's career night kept the 49ers in the hunt for the NFC's top seed and dampened the Colts' already faint playoff hopes.