49ers QB to miss game vs Arizona Cardinals
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Sep 7, 2025; Seattle, Washington, USA; San Francisco 49ers quarterback Brock Purdy (13) reacts following a failed third down play against the Seattle Seahawks during the fourth quarter at Lumen Field. Mandatory Credit: Joe Nicholson-Imagn Images / Joe Nicholson-Imagn Images
Tight end George Kittle suffered a hamstring in the Niners' 17-13 Week 1 win over the Seattle Seahawks and will miss multiple weeks. He is a candidate to be placed on injured reserve, which would mean missing a minimum of four games.
The 49ers are expected to be without starting quarterback Brock Purdy and tight end George Kittle, but they still have some weapons remaining on offense, and their defense is no picnic to deal with either.
The Arizona Cardinals and San Francisco 49ers won't see each other until Week 3 - though a massive name will now officially be absent in the NFC West
The San Francisco 49ers will be depending on Mac Jones to run its offense with Brock Purdy scheduled to miss at least two weeks with a turf toe injury.
USA TODAY Touchdown Wire on MSN13h
In the trenches: Saints run defense must slow down 49ers rushing attack
The 49ers want to run the football, and the New Orleans Saints might not be able to stop them. Winning in the trenches will be vital in Week 2:
Opening a regular season with two road victories has been auspicious for the San Francisco 49ers under coach Kyle Shanahan.
Saints Wire on MSN13h
3 Saints players to watch, and a critical X-factor in Saints vs. 49ers
Who's under pressure, and who is an X-factor? Why these players could be the difference in the New Orleans Saints' outcome against the 49ers:
New Orleans Saints head coach Kellen Moore speaks with the media ahead of Week 2 vs. the San Francisco 49ers from the Ochsner Sports Performance Center on Friday, September 12, 2025.
Niner Noise on MSN3d
Cardinals rookie is already making the 49ers regret passing on him
The San Francisco 49ers may have pulled out a win over the Seattle Seahawks in wild fashion in Week 1, but this team is still far from perfect. The lack of talent on defense could be the Achilles' heel that ruins their Super Bowl chances this season. For a team with aspirations this high, glaring weaknesses can't be swept under the rug.
Saints Wire on MSN1d
Saints vs. 49ers preview: Four key positions to watch in Week 2
With injuries hammering both teams ahead of Week 2, these are the positions that are most critical for a New Orleans Saints victory over the 49ers:
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