SPIRIT-HF missed its primary composite endpoint at 2 years, with higher observed event rates on spironolactone versus placebo ...

Meta-analysis of diagnostic test accuracy studies is an increasingly pivotal approach in evidence-based medicine, enabling the synthesis of data from multiple investigations to assess the performance ...

Objectives To evaluate the effects of brief bouts of exercise spread throughout the day, termed ‘exercise snacks’, on cardiorespiratory and muscular fitness, and cardiometabolic health outcomes in ...

Objective To evaluate the outcomes of pre-participation cardiovascular screening among National Collegiate Athletic Association (NCAA) athletes and quantify the added value of history and physical ...

The benefit of beta-blockers after myocardial infarction in patients with a preserved left ventricular ejection fraction (LVEF) is unclear. We conducted a meta-analysis at the individual-patient level ...

Background Sex-based differences in immune response are well established, but whether men and women derive comparable benefit ...

Despite data gaps in many countries, the burden of sickle cell disease, especially in west and central Africa, underscores ...