Fact checked by Nick Blackmer Tirzepatide and semaglutide, the ingredients in popular weight loss drugs, can both cause side effects, such as nausea, vomiting, and diarrhea.One is not safer than the other—tolerance to the medications largely depends on the patient.

In the first direct comparison study involving individuals with obesity, tirzepatide demonstrated approximately 50% greater weight loss compared to semaglutide. This landmark finding

The first clinical trial comparing semaglutide and tirzepatide, two popular, injectable weight-loss drugs, has been published, examining their ability to reduce weight and waist circumference. And one clearly comes out on top.