Heavy snow, ice and brutal cold are expected to make this winter storm a potentially life-threatening weather event, stretching across two-thirds of the U.S.

Follow live updates as a winter storm is expected to bring heavy snowfall, icy roads and cold temperatures across the United States.

Impacts from what could be the most significant storm of winter are expected to begin on Friday, spreading ice, snow and cold across much of the U.S.

A winter storm is heading for Pittsburgh, and while it's currently expected to dump a widespread 10 to 15 inches, those totals are likely to increase.

Over 160 million Americans are under winter hazards associated with the impending major winter storm. Disruptive snowfall is likely from the Southern Rockies to the Northeast, including dangerous ice from the ArkLaTex to the southern Mid-Atlantic. Here are the latest Key Messages pic.twitter.com/bmVIT5to7a

The major storm is set to hit starting on Jan. 23 and will stretch into the weekend, spreading snow and ice from the southern Plains to the Northeast.

The NYC area is bracing for a major winter storm that's set to hit the region with heavy snow on top of dangerous, subfreezing weather.