The biggest talking point in the 49ers’ game against the Chicago Bears was Trent Williams suffering a hamstring injury on the very first play. Widely regarded as one of the best at his position, Williams’ injury couldn’t have come at a worse time for the 49ers.

With the No. 1 seed at stake, the status of multiple 49ers Pro Bowlers is unclear for Saturday's showdown against the Seahawks.

Take a look at players who have been ruled out for the San Francisco 49ers Week 18 Saturday night matchup versus the Seattle Seahawks.

The 49ers will likely go without left tackle Trent Williams in Week 18, but tight end George Kittle expects to play. More at Pro Football Rumors.

Starting left tackle Trent Williams hasn't been ruled out for Saturday's game, but he didn't practice this week on his injured hamstring.

With Trent Williams dealing with an injury issue, the San Francisco 49ers elevated a veteran offensive lineman for Saturday's game.

49ers are listing LT Trent Williams (hamstring), TE George Kittle (ankle), and WR Ricky Pearsall (knee, ankle) as questionable for Saturday night’s game against Seattle for the NFC’s No. 1 seed. pic.twitter.com/Hwv9pTmSdd