This image illustrates the process of gene transcription within a cell. The DNA double helix unwinds to expose a specific sequence, allowing RNA polymerase to synthesize a complementary pre-mRNA ...

Discover how single-molecule Fiber-seq is revealing unexpected mechanisms of transcription factor regulation, chromatin ...

Transcription dynamics in the context of DNA damage response encompass the interactions between RNA polymerases and lesions within the DNA template, the resulting impact on transcriptional continuity, ...

Transcription-coupled DNA damage repair represents a specialised branch of nucleotide excision repair that ensures rapid removal of lesions from the transcribed strand of active genes. When RNA ...

A team led by researchers at UT Southwestern Medical Center has developed deep learning models to identify a simple set of rules that govern the activity of promoters—regions of DNA that initiate the ...

Every living cell transcribes DNA into RNA. This process begins when an enzyme called RNA polymerase (RNAP) clamps onto DNA. Within a few hundred milliseconds, the DNA double helix unwinds to form a ...

An essential cellular enzyme successfully transcribed synthetic DNA letters, bringing expanded genetic codes closer to ...

Researchers showed that E. coli RNA polymerase can accurately recognize and transcribe two synthetic base pairs, supporting ...

Researchers showed that the enzyme RNA polymerase can accurately read and transcribe an expanded, eight-letter genetic alphabet, not just DNA’s natural four-letter code. Using high-resolution ...

While scientists have studied the molecular steps involved in gene expression for decades, many questions still remain about this fundamental process. To transcribe genes, RNA polymerase II (RNA Pol ...

Throughout their lifespan, cells must continuously activate and deactivate genes. This process is regulated by transcription factors, a class of proteins that control gene expression by binding to DNA ...

Scientists have demonstrated RNA polymerase can read eight genetic letters. This enzyme accurately transcribes synthetic DNA, ...