The way Matthew Stafford and the Los Angeles Rams picked apart the injury-riddled defense for San Francisco, it raised questions about why the 49ers weren’t more aggressive before last week’s trade deadline.

It’s definitely a tough conference in my first year playing in it, and at this point we got to try and win every game we play in. Our backs are going to be

Matthew Stafford throws four touchdown passes, setting a Rams franchise record for the most in a three-game span.

A banner blasting the prospect of immigration enforcement at the Super Bowl flew in Santa Clara on Sunday amid tensions over the musician's upcoming performance.

San Francisco 49ers starting quarterback Brock Purdy won't be active again Sunday vs. the Los Angeles Rams according to a report.

Even though the odds of the San Francisco 49ers completing the comeback still would have been slim, Fox's officiating analyst said the referee crew's mistake late in Sunday's loss to the Rams took away a key first down.

San Francisco 49ers wide receiver Kendrick Bourne had a terrible first half in the Week 10 game against the Los Angeles Rams. Here's a closer look at what's happening in San Fran.