In mammals, autophagy is an evolutionarily conserved process where cytoplasmic components are typically degraded within the lysosome. Consequently, the degraded cargo is recycled depending on the ...

Schizophrenia (SCZ) is a severe and complex psychiatric disorder characterized by abnormalities in cognition and thought, with a worldwide lifetime prevalence of around 1% [1,2,3]. Due to the high ...

Alternative splicing is a fundamental biological process that allows cells to make many different types of mRNAs and proteins from a limited number of genes. For many animals, including humans, it is ...

Researchers at Lund University Faculty of Medicine have determined a novel mechanism linking the metabolism of ribonucleic acids, RNA, to the development of leukemia in myelodysplastic syndrome (MDS) ...

A recent study by TUS researchers reveal that the Cpeb4 protein may have a role in regulating osteoclast differentiation. This, in turn, could lead to the development of new therapeutic drugs for ...

A study in zebrafish shows that neuronal microexons regulate brain activity by modulating cAMP signaling. Loss of these ...

Researchers discover that disrupted neuronal microexons cause a permanent spike in cAMP signaling, driving severe hyperarousal, insomnia, and hyperactivity.

Large versus limited molecular profiling panel screening program in patients with metastatic sarcoma: An exploratory subgroup analysis from the ProfiLER 02 trial. This is an ASCO Meeting Abstract from ...

New research has identified sections of DNA associated with altered regulation of gene expression underlying schizophrenia. The implicated loci contribute to schizophrenia risk by affecting ...

The London Liver Cancer Score (LLCS): A novel and validated prognostic algorithm in hepatocellular carcinoma. This is an ASCO Meeting Abstract from the 2014 ASCO Annual Meeting I. This abstract does ...

The altered presence of tiny fragments of neuronal genes, called microexons, causes hyperarousal in zebrafish. This is the ...

RNA splicing is a major nexus of gene expression regulation, shaping cellular identity during development, frequently altered in human cancers. This process is mediated by a complex molecular ...