Protein sorting in the secretory pathway is essential for cellular compartmentalization and homeostasis in eukaryotic cells. The endoplasmic reticulum (ER) is the biosynthetic and folding factory of ...

Researchers have deciphered a biochemical mechanism that ensures that newly formed proteins are processed correctly when they leave the cell's own protein factories. This solves a decade-old puzzle in ...

Age is the single greatest risk factor for neurodegenerative disease, yet the cellular mechanisms that drive age-related protein accumulation in the brain remain incompletely understood. In ...