Recently, a novel DTx-based system was developed, which allows the short-term ablation of specific cells in vivo, called toxin receptor-mediated cell knockout. A single administration of DTx to ...

Although the pathophysiology of mesangial cells has long been considered to be the major factor in the development of glomerulosclerosis in type 1 or type 2 diabetes, more recent evidence suggests ...

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 14, entitled, "Inhibiting NLRP3 signaling in aging ...

Our kidneys are charged with the extraordinary task of filtering about 53 gallons of fluid a day, a process that depends on podocytes, tiny, highly specialized cells in the cluster of blood vessels in ...

The kidneys are vital organs that sustain life by filtering the blood and producing urine. This filtration process takes place in specialized structures called glomeruli, where podocytes play a ...

Podocytes are a terminally differentiated cell type located in the glomerulus. Podocyte damage and the subsequent dysregulation of podocyte proteins have been implicated in various kidney disorders.

Senior Postdoctoral Research Fellow, GOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics in Urology, Children's Hospital Los Angeles The glomerular filtration barrier, generated ...

Biomedical engineers at Duke University have developed a method to study how key cells in the kidneys become injured and deformed. The new model has revealed a significant mechanism behind severe ...

A study published in Advanced Healthcare Materials describes the bioengineering of three-dimensional (3D) kidney glomerular microtissues that replicate the glomerular filtration barrier (GFB) ...