The SportsLine Machine Learning Model has locked in its top Week 16 NFL anytime TD picks for players like Amon-Ra St. Brown, Bucky Irving and Omarion Hampton

The Atlanta Falcons and Arizona Cardinals will face off in a Battle of the Birds between two teams who are already looking ahead to the offseason. Despite both

The Houston Texans will face the Los Angeles Chargers on Saturday, with significant postseason stakes for both teams.

You can also see the model's best bets for every Week 15 NFL game. Finally, SportsLine expert RJ White, who is 141-120-5 (+1421) over his last 266 NFL picks, has locked in multiple Week 15 NFL picks. Visit SportsLine to see his best bets.

The Houston Texans are absolutely rolling right now with six straight wins, including the last four as underdogs. They’ll be big favorites on Sunday, though, as

Jauan Jennings has found the end zone in three straight games and five of his last six, highlighted by a two-touchdown performance in last week’s victory.

Watch the top touchdowns from Week 16 of the 2025 NFL season. Highlights from the Week 16 matchup between the San Francisco 49ers and the Indianapolis Colts during the 2025 NFL season.

Two AFC contenders will try to keep rolling Sunday when the Los Angeles Chargers host the Houston Texans in an NFL Week 17 matchup. Both are among the league's best defensive teams, with Houston (10-5) first in the league in yards allowed and Los Angeles (11-4) fourth.