APAP-induced DILI leads to dysregulation of ammonia levels. The negative modulation of miR-873-5p restores methionine cycle activity, attenuates ammonia accumulation, and increases polyamine synthesis ...
DHFR: dihydrofolate reductase; FH2: dihydrofolic acid; FH4: tetrahydrofolic acid; MTHFD: methylenetetrahydrofolate dehydrogenase; SHMT: hydroxymethyltransferase ...
Methionine adenosyltransferase 2A (MAT2A), the rate-limiting enzyme in the methionine cycle, catalyzes the formation of S-adenosylmethionine (SAM) from methionine and adenosine triphosphate (ATP).
Some brain cancers are easier to treat than others, and while many solid tumors can be removed surgically, others, such as diffuse midline gliomas (DMGs), are much trickier. The results of studies in ...
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