The Los Angeles Rams (6-2) will be hosted by the San Francisco 49ers (6-3) in Week 10 of the NFL season, and here’s our how to watch guide! This game should have big implications for the NFC West and the NFC as a whole as both the Rams and 49ers have looked like top-end teams throughout their first set of games of the season.

Matthew Stafford and the Rams look to extend their winning streak to four games when they face San Francisco at Levi's Stadium. The game is in progress (Fox).

Star quarterback Matthew Stafford has thrown his 400th touchdown pass in his career as Rams blow out 49ers in first half.

The Los Angeles Rams have been on fire as of late, but they're going into their most important game yet of the 2025 NFL season.