The Los Angeles Rams (6-2) will be hosted by the San Francisco 49ers (6-3) in Week 10 of the NFL season, and here’s our how to watch guide! This game should have big implications for the NFC West and the NFC as a whole as both the Rams and 49ers have looked like top-end teams throughout their first set of games of the season.

After the 49ers upset the Rams earlier in the season, Sean McVay claimed victory this time around in his coaching rivalry with his friend, Kyle Shanahan, thanks to Matthew Stafford.  The Rams' quarterback had a stellar performance on Sunday,

Expert recap and game analysis of the Los Angeles Rams vs. San Francisco 49ers NFL game from November 9, 2025 on ESPN.

WOODLAND HILLS, Ca. The Los Angeles Rams have finalized their roster before their week ten matchup against the San Francisco 49ers. Most of these moves were expected after the team committed to having a new approach in their kicking unit. McVay wanted Jake McQuaide as his long snapper due to his previous work and familiarity.

The Los Angeles Rams collected a 42-26 win on the road against NFC West rivals San Francisco 49ers on Sunday, but not before a worrisome injury development. In the fourth quarter of the contest, Los Angeles star wide receiver Davante Adams was seen leaving the field with an apparent upper-body injury.