Engineers have created DIAL, a modular system that precisely sets and edits protein levels in synthetic gene circuits. By ...

Biological rhythms aren't just for sleep. In the tiny worm C. elegans, researchers in the Grosshans lab and the Computational ...

Much of the phenotypic variation that is observed within and between species is the result of differences in gene regulation: specifically when, where and how much the genes are expressed. Given the ...

Molecular biologists have long believed that the beginning of a gene launched the process of transcription—the process by ...

Modified ChIP-seq and 4C-seq approaches, using urea-purified crosslinked chromatin, uncovered a two-tiered chromatin organization mediated by SATB1 that is linked to gene expression.

Polypurine hairpins are used to inhibit PCSK9 expression. When cholesterol levels in the blood rise too high, a condition known as hypercholesterolemia can develop, damaging arteries and threatening ...

Most people recognize Alzheimer's from its devastating symptoms such as memory loss, while new drugs target pathological aspects of disease manifestations, such as plaques of amyloid proteins. Now a ...