Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment ...

The initiation of chromosome replication is exquisitely regulated in both time and location. It has been estimated that there are 200-400 autosomal replication sequence elements (ARSs) in the yeast ...

Scientists have discovered a new property of the molecular motors that shape our chromosomes. While six years ago they found that these so-called SMC motor proteins make long loops in our DNA, they ...

A base editor rewrote a single DNA letter while editing human embryos, and every chromosome held even as mosaicism keeps a ...

Researchers at The University of Texas Medical Branch (UTMB) have identified how a key enzyme called ATR protects DNA from breaking when cells copy damaged genetic material, a discovery that could ...

Top: Chromosome separate with functioning SMC in two models, line drawing and filled-space. The red and pink dots indicate, respectively, ori on each copy of DNA. Bottom: DNA separating without ...

It's tricky to make an exact copy of yourself. Or at least it is for cells undergoing mitosis, where cells replicate everything inside of them, including their neatly packaged DNA, then split in half.

Half a century ago, scientists Jim Watson and Alexey Olovnikov independently realized that there was a problem with how our DNA gets copied. A quirk of linear DNA replication dictated that telomeres ...