Activation of the phosphatase calcineurin in intestinal epithelial cells (IECs) promotes intestinal tumour development, according to new research. Dysbiosis, commonly found early in colorectal cancer ...

Pimecrolimus and tacrolimus, 2 topical calcineurin inhibitors for the treatment of atopic dermatitis (AD), were not shown to increase the risk of cancer based on moderate-certainty evidence from a ...

Purpose. The effects of genetic polymorphisms on the pharmacokinetics of calcineurin inhibitors were examined. Pharmacogenetics examines the relationship between single-gene polymorphisms and the ...

Investigators compared the risk of cancer onset in patients with lupus nephritis treated with calcineurin inhibitors vs ...

Figure 1: a, Shift in calmodulin-associated CnA isoforms in the failing human left ventricle. Of the three calcineurin A isoforms (α, β and γ), CnA-β predominates in cardiac muscle. We extracted total ...

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Please provide your email address to receive an email when new articles are posted on . LOUISVILLE, Ky. — Researchers showed with moderate certainty that topical calcineurin inhibitors did not ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, No. 51 (December 21, 2010), pp. 22314-22319 (6 pages) In pancreatic β cells, ERK1 and ERK2 participate in ...

Cain/cabin1 is an endogenous inhibitor of calcineurin (Cn), a calcium-dependent serine/threonine phosphatase involved in various cellular functions including apoptosis. We show here that during ...

We were unable to process your request. Please try again later. If you continue to have this issue please contact [email protected]. Back to Healio The enzyme calcineurin may contribute to ...