Schematic representation of axonal transport vesicles (blue) carrying presynaptic proteins (SV and AZ proteins). Kinesin motor proteins (KIF1A) attach these vesicles and carry them along the axons to ...

A hallmark of Parkinson's disease is the buildup of Lewy bodies—misfolded clumps of the protein known as alpha-synuclein.

Neurotrophin signalling orchestrates a myriad of cellular events essential for the development, survival, and functional maintenance of sympathetic neurons. Neurotrophins such as nerve growth factor ...

Seeking students to contribute to research exploring motor-disease protein complexes and their role in intracellular transport, as they relate to disease initiation and the aging process, and the ...

Alzheimer's dementia is caused by accumulation of amyloid-β protein in neurons, formed from proteolytisis of amyloid precursor protein (APP), but the normal role of APP in the brain remains unclear.

Researchers found that inhibiting GSK-3 led to less defects in the axonal transport process and less neuronal cell death, while inhibiting ERK1 led to more transport problems and more cell death. A ...

Indiana University researchers in the College of Arts and Sciences in Bloomington have identified a missing link that can help protect the brain from aging. Carnegie Mellon University's Jessica Zhang ...

Huntington's disease is a genetic neurodegenerative disorder caused by mutations in the protein huntingtin and characterized by involuntary dance-like movements, severe behavioural changes and ...

Axons connect neurons across great distances in the nervous system, and this distance is a fundamental vulnerability for neurons. Maintenance of functional connectivity requires robust mechanisms for ...

Dysfunctional presenilin 1, infamous for misprocessing the amyloid precursor protein in familial Alzheimer’s disease, isn’t a one-trick pony. PS1 variants also weaken lysosomes, slow endosomal ...

Indiana University researchers in the College of Arts and Sciences in Bloomington have identified a missing link that can help protect the brain from aging. Carnegie Mellon University's Jessica Zhang ...