DEAR DR. ROACH: I’m an 88-year-old female who has been diagnosed with ventricular fibrillation. My cardiac electrophysiology doctor, who implanted a conventional pacemaker four years ago, has noticed ...

The carving up of the amyloid precursor protein (APP) by the successive action of β- and γ-secretases liberates Aβ, but also yields a small intracellular fragment, the APP intracellular domain (AICD).

Amyloid-β (Aβ) precursor protein (APP) has something of a mixed reputation. Mutations in the protein, or in its scissor enzyme presenilin, cause early onset familial Alzheimer disease (eFAD). On the ...

Dear Dr. Roach: I’m an 88-year-old female who has been diagnosed with ventricular fibrillation. My cardiac electrophysiology doctor, who implanted a conventional pacemaker four years ago, has noticed ...