The San Francisco 49ers finished their Week 10 contest with a 42-26 loss against the Los Angeles Rams at Levi's® Stadium.

Matthew Stafford and the Rams pull away in the fourth quarter to defeat the rival San Francisco 49ers 42-26 for their fourth consecutive victory.

WOODLAND HILLS, Ca. With a rematch against the 49ers on the mind, the Los Angeles Rams' superstars spoke on what the rivalry meant to them, using the questions as an opportunity to reflect on the growth experienced since their week five loss to San Francisco.

They’ll face a Rams team that stands atop the NFC West at 6-2, coming off three straight wins over the Baltimore Ravens, Jacksonville Jaguars, and the New Orleans Saints. All three of those victories have come by at least 14 points, with Los Angeles eclipsing the 30-point mark in the last two.

Sigler projected the 0-4 Saints to quickly become sellers ahead of the Nov. 4 trade deadline. One of his potential moves has the 49ers sending third and fourth-round picks in the 2026 draft to New Orleans in exchange for 28-year-old Northern California native Carl Granderson.

The Los Angeles Rams defeated their rival, the San Francisco 49ers in NFL week ten action. First Half First Quarter The Rams got the ball to open up the game, u

The MVP whispers around Matthew Stafford are getting louder. The Rams quarterback threw four touchdowns with no turnovers on Sunday to lead Los Angeles in a 42-26 romp in a critical NFC North matchup against the San Francisco 49ers.

The Los Angeles Rams face the San Francisco 49ers in an NFL game on Sunday, Nov. 9, 2025 at Levi’s Stadium in Santa Clara, California.

The Rams duo did not have a clean game last time out. The post NFL Announces Punishment for Rams Players After Saints Game appeared first on Heavy Sports.

The San Francisco 49ers couldn’t have been much worse in a Week 10 loss to the Los Angeles Rams. Here are the highlights.