The San Francisco 49ers suffered a brutal 42-26 loss to the Los Angeles Rams. The secondary struggled, and the absence of Fred Warner and Nick Bosa was painfully apparent. The game highlighted how much the team struggles against top-tier opponents.

Even though the odds of the San Francisco 49ers completing the comeback still would have been slim, Fox’s officiating analyst said the referee crew’s mistake late in Sunday's loss to the Rams took away a key first down.

All the energy in the world couldn’t overcome the 49ers losing two turnovers on a fumble by Jauan Jennings and an interception on fourth down by Jones. And also committing seven penalties for 45 yards to none for the Rams.

The 49ers (6-4) fell behind 21-0 early, yielded six touchdowns and produced no takeaways in a 42-26 loss to the Rams (7-2)

The 49ers are back in it. San Francisco, which trailed 21-0 early in the second quarter, has cut its deficit to 21-14 with 9:33 remaining in the third quarter. The 49ers scored a touchdown with 3:15 left in the first half on Jauan Jennings’ 6-yard touchdown reception. They opened the second half with a 10-play, 65-yard touchdown drive.