WOODLAND HILLS, Ca. The Los Angeles Rams are ready to play the San Francisco 49ers in a rematch of their week five overtime defeat. Taking on their arch rivals in enemy territory, Sean McVay looks to pick up a third straight win at Levi Stadium, something that he's never done in his head coaching career.

Five key talking points for Week 10 of the 2025 NFL season including the Colts facing the Falcons in Berlin and the Packers hosting the Eagles on Monday Night Football.

Other 49ers who are inactive against the Rams are wide receiver Ricky Pearsall Jr. (knee), running back Jordan James, guard Connor Colby, defensive tackle Sebastian Valdez and safety Marques Sigle.

The Los Angeles Rams, San Francisco 49ers and Seattle Seahawks each have six wins. Entering Week 10, the Rams have a 37.1% chance to win the division, followed by the 49ers (35.0%) and Seahawks (27.6%), according to ESPN Research.

How do all 32 teams in the NFL stack up against each other coming out of Week 8 of the 2025 NFL regular season? Here's an updated look from best to worst.

Defensively, the Eagles will return from their break with a bit of a different look after adding pass rusher Jaelan Phillips and defensive backs Jaire Alexander and Michael Carter at the trade deadline, while also welcoming outside linebacker Nolan Smith back from injury and defensive end Brandon Graham back from retirement.

We’re just days from the trade deadline, and almost halfway through the 2025 NFL Season! We have a few newcomers to the list this week, as a few backs have run their way onto the list. There’s been a bit of shakeup in the middle,

Philadelphia travels to Green Bay for a blockbuster NFC showdown. Plus, the Rams and 49ers face off in a Golden Coast rivalry.

Christian McCaffrey made history in San Francisco's Sunday win at the New York Giants as he set a new NFL record.

GREEN BAY – Here are five things to watch as the Green Bay Packers face the Arizona Cardinals on Sunday, Oct. 19 at State Farm Stadium in Glendale, Arizona.

Kyle Shanahan and Sean McVay have faced off 18 times leading their respective teams, with Shanahan currently holding an 11–7 edge over McVay. But those head-to-head matchups only tell part of the story of the rivalry between these two sides. While both men first got their shot at a top NFL job in 2017, their history goes back further.