The 49ers (6-4) fell behind 21-0 early, yielded six touchdowns and produced no takeaways in a 42-26 loss to the Rams (7-2)

Even though the odds of the San Francisco 49ers completing the comeback still would have been slim, Fox’s officiating analyst said the referee crew’s mistake late in Sunday's loss to the Rams took away a key first down.

The San Francisco 49ers have already lost Fred Warner for the year, and now they may have to play without his replacement.

The Los Angeles Rams (7-2) are cooking. Fans and pundits are thinking Super Bowl. Matthew Stafford and the Rams torched the San Francisco 49ers (6-4) on Sunday, 42-26, led by the veteran quarterback's 280 passing yards and four touchdowns.

The Los Angeles Rams knew that they would play Mac Jones on Sunday after the San Francisco 49ers made that announcement earlier this week. Jones, who has been dealing with an injury while playing throughout the entire season, enters Sunday's contest with an issue with his knees.

Los Angeles Rams cornerback Emmanuel Forbes scoops up a deflected pass from San Francisco 49ers quarterback Mac Jones for an interception.

San Francisco 49ers starting quarterback Brock Purdy won't be active again Sunday vs. the Los Angeles Rams according to a report.

The 49ers are back in it. San Francisco, which trailed 21-0 early in the second quarter, has cut its deficit to 21-14 with 9:33 remaining in the third quarter. The 49ers scored a touchdown with 3:15 left in the first half on Jauan Jennings’ 6-yard touchdown reception. They opened the second half with a 10-play, 65-yard touchdown drive.