NFL, Los Angeles Rams and San Francisco 49ers
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And it had the NFL community taking the team very seriously as a top contender:
Los Angeles beat division rival San Francisco in convincing fashion, 42-26. Rams quarterback Matthew Stafford passed for 280 yards and four touchdowns, including going over 400 for his career. Stafford is only the ninth QB to join the 400 TD pass club in NFL history.
Familiar matchups abound on the NFL Week 10 schedule as there are half a dozen divisional games you can make Week 10 NFL picks on. The highlight of that slate is Rams vs. 49ers, which has L.A. as the 5.
Video highlights, recaps and play breakdowns of the Los Angeles Rams vs. San Francisco 49ers NFL game from November 9, 2025 on ESPN.
An incident involving San Francisco 49ers star running back Christian McCaffrey led to a punishment from the NFL this weekend.
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Kyren Williams punched it in from two yards out for a touchdown, giving the Los Angeles Rams an early lead over the San Francisco 49ers.