In this White Paper, MatTek, now part of Sartorius, details a highly differentiated 3D small-intestine tissue model that uses primary human stem cells to provide a more accurate alternative to animal ...

Infectious microbes have evolved sophisticated means to invade host cells, outwit the body's defenses and cause disease. While researchers have tried to puzzle out the complicated interactions between ...

Researchers have developed a protocol to transplant 3D cellular structures called organoids into the damaged colon and intestine of mice. Once delivered via rectal infusion, the organoids are able to ...

The intestinal epithelium of our body consists of a myriad of elongated villi microarchitectures which increase the total surface area of the inner wall for better absorption of digested nutrients.

Some of the most intractable gastrointestinal disorders, such as irritable bowel syndrome and inflammatory bowel disease, are motility disorders, where the contents of the intestines don’t proceed ...

Ulcerative colitis is an inflammatory bowel disease (IBD) that causes inflammation and ulcers (sores) in the digestive tract. Ulcerative colitis affects the innermost lining of the colon and rectum.

In vivo, the intestinal epithelium interacts with the neighboring environment through complex crosstalk, which involves components such as the immune system, tissue microenvironment, and gut microbes.

NAMkind™ models have now been tested against a wide set of marketed ADC molecules, showing close correlation with clinical results in terms of the toxic impact in the liver and side effect profile in ...